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Relapse during the double-blind phase was defined as the following conditions being met on two consecutive visits: (1) CGI-I ≥ 3; (2) CAPS-2 score increased by ≥ 30% and by ≥ 15 points relative to baseline; and (3) worsening of the patient's condition in the investigator's judgment.
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En effet, il ne faut pas oublier que les génériques sont toujours produits bien après les médicaments originaux (en général 5 ou 10 ans, selon les brevets et les législations) et qu’ils bénéficient donc des progrès accomplis par la médecine entre-temps.
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One of the side effects of Retin A is that acne may worsen before it gets better.
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Drug prices in the United States are instead set in hundreds of negotiations by hospitals, insurers and pharmacies with drug manufacturers, with deals often brokered by powerful middlemen called group purchasing organizations and pharmacy benefit managers, who leverage their huge size to demand discounts.

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